Dietary advice in hypercholesterolemia. Relation of selected dietary factors to total serum cholesterol and high density lipoprotein cholesterol

• Published in: Ugeskrift for læger Vol. 151; no. 35; p. 2206
• Main Authors: Andersen, M M, Ebbesen, K, Hess, K, Idorn, M L, Simonÿ, K
• Format: Journal Article
• Language: Danish
• Published: Denmark 28-08-1989
• Subjects: Adult; Aged; Cholesterol - blood; Cholesterol, HDL - blood; Female; Follow-Up Studies; Humans; Hypercholesterolemia - blood; Hypercholesterolemia - diet therapy; Male; Middle Aged
• ISSN: 0041-5782

Forty patients (14 women and 26 men) with slight to moderate hypercholesterolaemia received dietary advice and were followed-up for 12 weeks, the majority for 26 weeks. After 12 weeks, the total cholesterol had decreased by an average of 12% (from 7.92 to 6.97 mmol/l), the high density lipoprotein (HDL) cholesterol had increased by 5.3% (from 1.14 to 1.20 mmol/l) and thus the ratio of total cholesterol/HDL cholesterol had decreased by 17% (from 7.42 to 6.15). In the 35 patients who were followed-up for 26 weeks, the total cholesterol/HDL cholesterol decreased further (to 22% below the original value). HDL cholesterol was found by univariate regression analysis to be correlated significantly with the dietary content of the patients of fats (negative), polyunsaturated fatty acids (positive), sugar (negative), fibre (positive) and the total value (positive). Employing multivariate analysis with stepwise reduction, fats and fish sandwich spreads were found to be significantly correlated. The ratio of total cholesterol/HDL cholesterol by means of univariate analysis was found to be inversely correlated with the same dietary factors as HDL cholesterol while multivariate analysis revealed the content of polyunsaturated fatty acids, sugar and alcohol intake to be significantly correlated.