In vitro studies on the adsorption of various resins of the Wofatit type for drugs

The capacities of the resins Wofatit Y 29, Y 55 and Y 56 (VEB Chemiekombinat Bitterfeld) to adsorb various medicaments were compared with that of the resin XAD-4. Methaquelone, diazepam, krotylbarbital, promazine phosphate and ethyloxamine were used as test substances. The resin Y 56 proved to have...

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Bibliographic Details
Published in:	Zeitschrift fur Urologie und Nephrologie Vol. 76; no. 2; p. 87
Main Authors:	Stein, G, Böhme, R, Demme, U, Werner, R, Schwachula, G, Günther, K
Format:	Journal Article
Language:	German
Published:	Germany 1983
Subjects:	Barbiturates - analogs & derivatives Barbiturates - blood Diazepam - blood Hemoperfusion Humans Methaqualone - blood Poisoning - blood Poisoning - therapy Promazine - blood Resins, Synthetic
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Summary:	The capacities of the resins Wofatit Y 29, Y 55 and Y 56 (VEB Chemiekombinat Bitterfeld) to adsorb various medicaments were compared with that of the resin XAD-4. Methaquelone, diazepam, krotylbarbital, promazine phosphate and ethyloxamine were used as test substances. The resin Y 56 proved to have an adsorption capacity similar to that of XAD-4 (e.g. maximum saturation for methaquelone 98%, half-maximum saturation at 7 minutes). In further tests on various batches of this resin the best results were given by the resin Y 56/7. Adsorption was quite clearly shown to be dependent on concentration. At a blood-flow of 100 ml/min clearance values of 34.5 ml/min for krotylbarbitol and 22.1 ml/min for methaquelone were calculated. According to these findings the resin Y 56/7 is suitable for further testing in a haemoperfusion system with a view to clinical use.
ISSN:	0044-3611