Coupling of transcription and translation as the factor regulating the transcription of genes rpoBC in Escherichia coli cells

The natural transcription polarity of proximal and distal elements of the rplJL-rpoBC operon is increased when translation is inhibited in Escherichia coli cells. It is shown that transcription uncoupling to translation terminates within EcoRI-2,6 fragment of the operon which contains the transcript...

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Bibliographic Details
Published in:	Genetika Vol. 19; no. 3; p. 435
Main Authors:	Lideman, L F, Ponomarenko, O I, Shakulov, R S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1983
Subjects:	Chloramphenicol - pharmacology DNA, Bacterial - genetics Escherichia coli - drug effects Escherichia coli - genetics Gene Expression Regulation - drug effects Genes, Bacterial - drug effects Nucleic Acid Hybridization - drug effects Operon - drug effects Plasmids - drug effects Protein Biosynthesis - drug effects Transcription, Genetic - drug effects
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Summary:	The natural transcription polarity of proximal and distal elements of the rplJL-rpoBC operon is increased when translation is inhibited in Escherichia coli cells. It is shown that transcription uncoupling to translation terminates within EcoRI-2,6 fragment of the operon which contains the transcription attenuator. We suggest that transcription attenuation in the rplJL-rpoBC operon is regulated by the coupling of transcription to translation of the intergenic fragment which overlaps the attenuator sequence.
ISSN:	0016-6758