The place of 99mTc-MDP skeletal scintigraphy in neuroblastoma. Is a new assessment necessary?

The present study compares the reliability of MIBG and MDP bone scans in detecting bone metastases of neuroblastoma. Out of 57 patients, 23 had both 99mTc-MDP and 123I/131I-MIBG scans within a 2-week period. In 10 patients at primary diagnosis there was an underestimation of skeletal involvement by...

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Bibliographic Details
Published in:	Nuclear medicine Vol. 30; no. 1; p. 7
Main Authors:	Sautter-Bihl, M L, Bihl, H, Heinze, H G
Format:	Journal Article
Language:	German
Published:	Germany 01-02-1991
Subjects:	3-Iodobenzylguanidine Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Child Child, Preschool Ganglioneuroma - diagnostic imaging Ganglioneuroma - secondary Humans Infant Iodine Radioisotopes Iodobenzenes Neuroblastoma - diagnostic imaging Neuroblastoma - secondary Radionuclide Imaging Technetium Tc 99m Medronate
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Summary:	The present study compares the reliability of MIBG and MDP bone scans in detecting bone metastases of neuroblastoma. Out of 57 patients, 23 had both 99mTc-MDP and 123I/131I-MIBG scans within a 2-week period. In 10 patients at primary diagnosis there was an underestimation of skeletal involvement by MIBG in 1/5, in 13 patients at follow-up in 3/9; 99mTc-MDP scans were able to visualize skeletal involvement in all those cases. There was only one false positive MDP scan. These results suggest that MIBG alone may fail to visualize skeletal involvement of neuroblastoma and should therefore be complemented by additional 99mTc-MDP scintigraphy.
ISSN:	0029-5566