Effects of urologic surgery on lymphocyte blastogenic response to phytohemagglutinin

• Published in: Actas urologicas españolas Vol. 13; no. 6; p. 415
• Main Authors: Gil Salmon, M, Espi Macias, A, Chuan Nuez, P, Arenas Ricart, J, Clar Blanch, F, Carretero González, P, García-Lomas, J
• Format: Journal Article
• Language: Spanish
• Published: Spain 01-11-1989
• Subjects: Aged; Aged, 80 and over; Female; Humans; Immunity, Cellular; Kidney Calculi - immunology; Kidney Calculi - surgery; Lymphocyte Activation; Male; Middle Aged; Phytohemagglutinins - pharmacology; Postoperative Period; Prostatic Hyperplasia - immunology; Prostatic Hyperplasia - surgery; Urinary Bladder Neoplasms - immunology; Urinary Bladder Neoplasms - surgery
• ISSN: 0210-4806

In order to study the effect of urological surgery on the defence system, we have evaluated the postoperative evolution of the lymphocyte blastogenic response to phytohemagglutinin (PHA) in 45 patients. 25 of them were subjected to a transurethral resection (TUR) of a vesical tumour, 10 to a transvesical prostatectomy, 6 to a pyelolithotomy and 4 to a nephrectomy due to renal atrophy secondary to lithiasis. We verified a significant drop in the lymphocyte blastogenic response to PHA at 2-4 hours of transvesical prostatectomy (p less than 0.001) and of pyelolithotomy and nephrectomy (p less than 0.001) which was sustained until the fourth and second day after operation respectively, with subsequent return to normal. However, lymphocyte blastogenic response to PHA did not vary significantly during the postoperative of patients subjected to a TUR of vesical tumours. On the whole, the degree and duration of postoperative immunodepression was dependent on the intensity of the surgical traumatism.