Pseudomonas microcins: characterization and effect of iron concentration

Antibacterial substances were found in Pseudomonas, they were heat and trypsin resistant, molecular weight less than 10,000 daltons, produced in minimal media, optimum pH 7.0. Methionine and glycine inhibited them; other amino acids produced less antagonistic effect. An inverted relationship between...

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Bibliographic Details
Published in:	Revista latinoamericana de microbiología (1970) Vol. 36; no. 2; p. 101
Main Authors:	Barberis, I L, Pájaro, M C, Albesa, I
Format:	Journal Article
Language:	Spanish
Published:	Mexico 01-04-1994
Subjects:	Bacteriocins - antagonists & inhibitors Bacteriocins - isolation & purification Bacteriocins - pharmacology Culture Media Glycine - pharmacology Hot Temperature Iron - pharmacology Methionine - pharmacology Microbial Sensitivity Tests Molecular Weight Pseudomonas - drug effects Pseudomonas - metabolism Pseudomonas aeruginosa - drug effects Species Specificity Staphylococcus aureus - drug effects
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Summary:	Antibacterial substances were found in Pseudomonas, they were heat and trypsin resistant, molecular weight less than 10,000 daltons, produced in minimal media, optimum pH 7.0. Methionine and glycine inhibited them; other amino acids produced less antagonistic effect. An inverted relationship between susceptibility to microcin and Fe3+ concentration was observed in experiments with iron-depleted strains. Pseudomonas was sensitive to its own microcin in iron-free medium; this is an important finding in the study of the immunity of microcin-producing strains.
ISSN:	0187-4640