Chronic calculous cholecystitis: elementary and dysplastic lesions, echographic correlations and immunohistochemical approach

• Published in: Pathologica Vol. 84; no. 1090; p. 171
• Main Authors: Pingitore, R, Bonucci, M, Bigini, D, Ciancia, E M, Vignati, S
• Format: Journal Article
• Language: Italian
• Published: Italy 01-03-1992
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, Tumor-Associated, Carbohydrate - analysis; Biomarkers; Carcinoembryonic Antigen - analysis; Cholecystitis - etiology; Cholecystitis - pathology; Cholelithiasis - complications; Cholelithiasis - pathology; Chronic Disease; Female; Gallbladder - pathology; Gallbladder Neoplasms - pathology; Humans; Incidence; Male; Middle Aged; Mucous Membrane - pathology; Precancerous Conditions - epidemiology; Precancerous Conditions - pathology; Preoperative Care
• ISSN: 0031-2983

The morphological analysis of 223 cases of chronic calculous cholecystitis has drawn attention to the following outstanding facts: (a) elementary lesions are numerous (above all ulceration, mucosal erosion, antral and intestinal metaplasia) and put together a complex sight; (b) mild, moderate and severe dysplasias have a surprising high incidence (67%), even in the age-group under 40; (c) dysplasia is more common in the gallbladders bearing parallel hyperplastic and metaplastic mucosal changes, if compared with gallbladders where these changes are lacking; (d) thickness of gallbladder's wall and incidence of dysplasia are in direct relation; (e) echographic preoperative assessment of wall's thickness has predictive value for presence of dysplasia; (f) CEA and CA 19-9 have a progressively increasing expression in the various degrees of dysplasia.