Treatment of advanced prostatic carcinoma with ketoconazole. Our experience in 10 cases

We have treated 10 patients with histologically diagnosed prostate carcinoma, in states C and D, with orally administered dosage of 1200 mg./day of ketoconazol, with the following results: Four patients were excluded through displaying gastrointestinal intolerance in the first days of treatment. Thr...

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Bibliographic Details
Published in:	Actas urologicas españolas Vol. 13; no. 2; p. 82
Main Authors:	Clar Blanch, F, Galan Brotons, A, Chuan Nuez, P, Gil Salom, M, Santamaría Meseguer, J, Carretero González, P
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-03-1989
Subjects:	Aged Aged, 80 and over Humans Ketoconazole - therapeutic use Male Middle Aged Prostatic Neoplasms - drug therapy
Online Access:	Get more information
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Summary:	We have treated 10 patients with histologically diagnosed prostate carcinoma, in states C and D, with orally administered dosage of 1200 mg./day of ketoconazol, with the following results: Four patients were excluded through displaying gastrointestinal intolerance in the first days of treatment. Three patients treated had the dosage reduced to half due to poor tolerance, but no improvement was noted. Another three patients tolerated the treatment for four months and displayed transitory remission of ostealgia, which permitted the withdrawal of analgesics. In these patients the treatment was suspended due to digestive intolerance and to the appearance of a clinical picture compatible with suprarrenal corex hypoadrenalism.
ISSN:	0210-4806