Immunochemical study of the embryonal prealbumin-2 (EPA-2) in embryonal and adult human tissues

Embryonal prealbumin-2 /EPA-2/ was shown to be a protein, which was actively synthesized in fetus during embryogenesis. The highest content of EPA-2 was found in soft fetal tissues; this suggesting that the protein synthesis occurred in organs of mesodermal origin. To the moment of delivery the cont...

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Bibliographic Details
Published in:	Voprosy meditsinskoi khimii Vol. 27; no. 2; p. 259
Main Authors:	Kalashnikov, V V, Voloshchuk, S G, Falaleeva, D M, Tatarinov, Iu S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1981
Subjects:	Adult Digestive System - analysis Female Fetus - analysis Humans Immunodiffusion Muscles - analysis Neoplasms - analysis Prealbumin - analysis Pregnancy Serum Albumin - analysis Skin - analysis Spleen - analysis Tissue Distribution
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Summary:	Embryonal prealbumin-2 /EPA-2/ was shown to be a protein, which was actively synthesized in fetus during embryogenesis. The highest content of EPA-2 was found in soft fetal tissues; this suggesting that the protein synthesis occurred in organs of mesodermal origin. To the moment of delivery the content of EPA-2 in fetus was distinctly decreased and the protein was not detected using the immunodiffusion technique in blood serum of adult persons, i e. the EPA-2 synthesis was markedly reduced. Low content of EPA-2 was observed in human gastrointestinal tract, locomotive system, spleen and skin tissues. The EPA-2 synthesis was increased distinctly in malignant tumors, especially, of connective tissue, whereas in tumors of epithelial tissue the content of EPA-2 often depended on presence of connective tissue elements.
ISSN:	0042-8809