Structural changes of chromatin during proto-oncogene activation by cycloheximide: dose-effect

The level of expression of cellular proto-oncogens c-myc and c-fos in rat liver has been studied as a function of protein synthesis rate (cycloheximide dose). Activation of proto-oncogens has been established to be initiated by 50% inhibition of nuclear protein synthesis. This promotes a certain lev...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 57; no. 10; p. 1491
Main Authors:	Shevchenko, N A, Spitkovskiĭ, D D, Loginov, A S, Makar'eva, E D, Boĭkov, P Ia
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-10-1992
Subjects:	Animals Calcium - metabolism Cations, Divalent Cell Nucleus - metabolism Chromatin - chemistry Chromatin - drug effects Cycloheximide - pharmacology Deoxyribonucleases - metabolism Dose-Response Relationship, Drug Gene Expression Genes, fos Genes, myc Liver - metabolism Magnesium - metabolism Male Protein Conformation Proto-Oncogenes Rats
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Summary:	The level of expression of cellular proto-oncogens c-myc and c-fos in rat liver has been studied as a function of protein synthesis rate (cycloheximide dose). Activation of proto-oncogens has been established to be initiated by 50% inhibition of nuclear protein synthesis. This promotes a certain level in chromatin structural rearrangements which is manifested, in particular, in decreasing activity of chromatin cleavage by Ca2+, Mg(2+)-DNAase and increasing degree of chromatin condensation. A role of topoisomerase II in chromatin structural rearrangements during proto-oncogen activation is postulated.
ISSN:	0320-9725