Effect of local anesthetics on the transport of mannose in the microsomal membranes of Aspergillus niger van Tieghem

The influence of various local anaesthetics has been studied on the mannose transfer enzymic system which is localized in Aspergillus niger van Tieghem microsomal membranes. The n-alkanes and tertiary amines do not seem to react on the first step of the reaction: i.e. the polyprenylphosphate-mannose...

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Bibliographic Details
Published in:	Chemico-biological interactions Vol. 35; no. 3; p. 297
Main Authors:	Létoublon, R, Got, R
Format:	Journal Article
Language:	French
Published:	Ireland 01-06-1981
Subjects:	Alkanes - pharmacology Amines - pharmacology Anesthetics, Local - pharmacology Aspergillus niger - drug effects Aspergillus niger - enzymology Biological Transport - drug effects Intracellular Membranes - enzymology Kinetics Mannose - metabolism Microsomes - enzymology
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Summary:	The influence of various local anaesthetics has been studied on the mannose transfer enzymic system which is localized in Aspergillus niger van Tieghem microsomal membranes. The n-alkanes and tertiary amines do not seem to react on the first step of the reaction: i.e. the polyprenylphosphate-mannose biosynthesis. However two amines, the dibucaine and to a lesser extent the tetracaine, inhibit the mannose transfer from the polyprenylphosphate-mannose to the endogenous proteins.
ISSN:	0009-2797