Design of a recombinant strain of the vaccinia virus containing an expressible gene for influenza A virus hemagglutinin
A recombinant vaccinia virus (VV) strain containing a cloned gene of influenza A/Udorn/307/72 (H3N2) hemagglutinin (HA) gene has been produced. HA expression in CV-1 cells infected with the recombinant virus was determined by enzyme immunoassay. The influenza virus HA titer was 1:64-1:128. When rabb...
Saved in:
Published in: | Voprosy virusologiĭ Vol. 33; no. 3; p. 275 |
---|---|
Main Authors: | , , , , |
Format: | Journal Article |
Language: | Russian |
Published: |
Russia (Federation)
01-05-1988
|
Subjects: | |
Online Access: | Get more information |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | A recombinant vaccinia virus (VV) strain containing a cloned gene of influenza A/Udorn/307/72 (H3N2) hemagglutinin (HA) gene has been produced. HA expression in CV-1 cells infected with the recombinant virus was determined by enzyme immunoassay. The influenza virus HA titer was 1:64-1:128. When rabbits were inoculated intravenously with the recombinant VaV, antibody titres were 1:5120. The recombinant VaV preparation may be used for generation of monospecific antibody to influenza virus. |
---|---|
ISSN: | 0507-4088 |