Effect of protein-free diet on sulfobromophthalein hepatic transport (author's transl)

Initial plasma disappearance rate and biliary excretion of intravenously injected sulfobromophthalein were studied in Wistar female rats fed a normal or a protein-free diet. Proteins and sulfobromophthalein distribution in the liver were studied by a gel filtration method. The results suggest that p...

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Bibliographic Details
Published in:	Acta physiologica latinoamericana Vol. 25; no. 3; p. 197
Main Authors:	Rodríguez Garay, E A, Morisoli, L S, Rosario Spetale, M D, Rassero, J A
Format:	Journal Article
Language:	Spanish
Published:	Argentina 1975
Subjects:	Animals Bile - analysis Dietary Proteins - administration & dosage Female Liver - metabolism Liver Function Tests Protein Binding Protein Deficiency - metabolism Proteins - metabolism Rats Sulfobromophthalein - analysis
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Summary:	Initial plasma disappearance rate and biliary excretion of intravenously injected sulfobromophthalein were studied in Wistar female rats fed a normal or a protein-free diet. Proteins and sulfobromophthalein distribution in the liver were studied by a gel filtration method. The results suggest that protein deficiency may produce an impaired sulfobromophthalein transference from plasma to liver cell due to a reduction of total hepatic proteins and of sulfobromophthalein-binding protein fraction responsible for liver uptake.
ISSN:	0001-6764