Comparative evaluation of the protective effect of sodium valproate, phenazepam and ionol in stress-induced liver damage in rats

Ionol, a synthetic antioxidant, limits the stressor liver injury to a greater extent than sodium, valproate and phenazepam, activators of a GABA-ergic link of the stress-limiting organism systems. This injury is exhibited in the organospecific elevated levels of blood enzymes fructosediphosphate ald...

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Bibliographic Details
Published in:	Fiziologicheskii zhurnal Vol. 37; no. 3; p. 66
Main Authors:	Nikonorov, A A, Tverdokhlib, V P
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-05-1991
Subjects:	Animals Anti-Anxiety Agents Antioxidants - pharmacology Benzodiazepines Benzodiazepinones - pharmacology Butylated Hydroxytoluene - pharmacology Cytochrome P-450 Enzyme System - deficiency Enzyme Activation - drug effects Enzyme Activation - physiology Fructose-Bisphosphate Aldolase - antagonists & inhibitors Fructose-Bisphosphate Aldolase - blood Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Male Microsomes, Liver - drug effects Microsomes, Liver - metabolism Rats Stress, Psychological - metabolism Valproic Acid - pharmacology
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Summary:	Ionol, a synthetic antioxidant, limits the stressor liver injury to a greater extent than sodium, valproate and phenazepam, activators of a GABA-ergic link of the stress-limiting organism systems. This injury is exhibited in the organospecific elevated levels of blood enzymes fructosediphosphate aldolase depression of N-demethylase activity of microsomal monooxygenases and a decrease in the amount of cytochromes P-450 and B5.
ISSN:	0201-8489