Effect of ACTH fragments on the aggressive-defensive behavior of the rat

ACTH4-10 and ACTH5-10 enhanced the fear response and footshock-induced aggression in male rats (50 and 150 mcg/kg, i.p.). ACTH4-10 seemed to produce the corticotropin (ACTH1-39) neuromodulatory behavioral effect which involved the facilitation of the brain muscarinic receptor activation.

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Bibliographic Details
Published in:	Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova Vol. 72; no. 12; p. 1614
Main Authors:	Sever'ianova, L A, Plotnikov, D V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-12-1986
Subjects:	Adrenocorticotropic Hormone - analogs & derivatives Adrenocorticotropic Hormone - pharmacology Aggression - drug effects Animals Brain - drug effects Desoxycorticosterone - pharmacology Fear - drug effects Hydrocortisone - pharmacology Male Peptide Fragments - pharmacology Rats Rats, Inbred Strains Receptors, Muscarinic - drug effects
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Description
Summary:	ACTH4-10 and ACTH5-10 enhanced the fear response and footshock-induced aggression in male rats (50 and 150 mcg/kg, i.p.). ACTH4-10 seemed to produce the corticotropin (ACTH1-39) neuromodulatory behavioral effect which involved the facilitation of the brain muscarinic receptor activation.
ISSN:	0015-329X