Effect of chlorgyline on gamma-aminobutyric acid levels in hyperoxia

Chlorgyline, an inhibitor of type A monoamine oxidase, administered to rats prevented oxygen-induced decrease in gamma-aminobutyric acid brain content in hyperoxia. At the same time chlorgyline had an overall protective effect, increasing two-fold the period prior to the development of oxygen convul...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 101; no. 1; p. 45
Main Authors:	Goroshinskaia, I A, Sherstnev, K B
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1986
Subjects:	Animals Brain - metabolism Clorgyline - pharmacology Female gamma-Aminobutyric Acid - metabolism Male Oxygen - toxicity Propylamines - pharmacology Rats Seizures - chemically induced Seizures - metabolism Seizures - prevention & control
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Summary:	Chlorgyline, an inhibitor of type A monoamine oxidase, administered to rats prevented oxygen-induced decrease in gamma-aminobutyric acid brain content in hyperoxia. At the same time chlorgyline had an overall protective effect, increasing two-fold the period prior to the development of oxygen convulsions. The data suggest an important role of the modification of monoamine oxidase catalytic properties in the development of oxygen-induced intoxication and, particularly, in the decrease of gamma-aminobutyric acid content in hyperoxia.
ISSN:	0365-9615