Activation of nuclear polypeptide synthesis in rat liver cells after inhibition of template protein synthesis. The role of nuclear polypeptide synthesis in the changes of the chromatin structure

The correlation between the rates of nuclear polypeptide synthesis (NPS) and matrix protein synthesis in rat liver cells was investigated. It was shown that NPS is activated under conditions of protein synthesis inhibition in the cytoplasm. Model experiments revealed that the NPS and ADP ribosylatio...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 50; no. 12; p. 1990
Main Authors:	Gutnikova, M N, Shevchenko, N A, Boĭkov, P Ia, Mitrokhin, Iu I, Todorov, I N
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-12-1985
Subjects:	Adenosine Diphosphate Ribose - metabolism Animals Cell Nucleus - metabolism Chromatin - metabolism Cycloheximide - pharmacology Depression, Chemical Kinetics Liver - metabolism Male Peptide Biosynthesis Protein Conformation Rats Ribosomes - metabolism Templates, Genetic Time Factors
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Summary:	The correlation between the rates of nuclear polypeptide synthesis (NPS) and matrix protein synthesis in rat liver cells was investigated. It was shown that NPS is activated under conditions of protein synthesis inhibition in the cytoplasm. Model experiments revealed that the NPS and ADP ribosylation systems compete for chromatin structure: ADP ribosylation induces condensation, while NPS--decondensation of chromatin.
ISSN:	0320-9725