Antigenic structure of the foot-and-mouth virus. VI. Functional segments of the immunodominant region of the VP1 protein of foot-and-mouth virus strains O1K and A22

B- and T-epitopes have been localized within the protective fragments of VP1 protein, viz., 136-152 of the O1K strain and 135-159 of the A22 strain of the foot-and-mouth disease virus (FMDV). Antibodies eliciting after immunization of various animals with the 135-159 A22 peptide are directed to diff...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 17; no. 5; p. 596
Main Authors:	Gel'famov, V M, Grechaninova, L A, Kan, E S, Iarov, A V, Surovoĭ, A Iu, Vol'pina, O M, Chepurkin, A V, Ivanov, V T
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-1991
Subjects:	Amino Acid Sequence Animals Antibodies, Viral - immunology Antigens, Viral - immunology Aphthovirus - immunology B-Lymphocytes - immunology Capsid - genetics Capsid - immunology Capsid Proteins Epitopes - immunology Mice Mice, Inbred Strains Molecular Sequence Data Peptide Fragments - immunology Species Specificity T-Lymphocytes - immunology
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Summary:	B- and T-epitopes have been localized within the protective fragments of VP1 protein, viz., 136-152 of the O1K strain and 135-159 of the A22 strain of the foot-and-mouth disease virus (FMDV). Antibodies eliciting after immunization of various animals with the 135-159 A22 peptide are directed to different sites of the peptide. Immunogenicity of fragments of the 135-159 A22 peptide on mice correlates with their activity on T-cells of the same animals and protective activity on guinea pigs. The investigations were carried out using synthetic fragments of the 136-152-O1K and 135-159-A22 peptides.
ISSN:	0132-3423