Bleomycetin antitumor activity in relation to solid mouse tumors

The antitumor activity of bleomycetin or bleomycin A5 was studied with respect to sarcoma 180, Garding-Passey melanoma, cervical carcinoma CC-5 and lymphosarcoma L10-1. Bleomycetin showed a high selective effect on the solid form of sarcoma 180. Its activity against Garding-Passeys melanoma and cerv...

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Bibliographic Details
Published in:	Antibiotiki Vol. 26; no. 9; p. 694
Main Authors:	Bazhanov, V S, Shorin, V A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1981
Subjects:	Animals Bleomycin - therapeutic use Drug Evaluation, Preclinical Female Lymphoma, Non-Hodgkin - drug therapy Male Melanoma - drug therapy Mice Mice, Inbred C3H Mice, Inbred CBA Neoplasm Transplantation Neoplasms, Experimental - drug therapy Sarcoma 180 - drug therapy Uterine Cervical Neoplasms - drug therapy
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Summary:	The antitumor activity of bleomycetin or bleomycin A5 was studied with respect to sarcoma 180, Garding-Passey melanoma, cervical carcinoma CC-5 and lymphosarcoma L10-1. Bleomycetin showed a high selective effect on the solid form of sarcoma 180. Its activity against Garding-Passeys melanoma and cervical carcinoma CC-5 was lower. Lymphosarcoma L10-1 was most resistant to bleomycetin. The intravenous route of bleomycin administration had no advantages over subcutaneous administration of the antibiotic.
ISSN:	0003-5637