Comparative study of the genetic effect of various tritium compounds in male mice

Comparative study of the genetic effect of some tritiated biogenic++ compounds and tritiated water was carried out. Reciprocal translocations induced in mice stem spermatogonia by 3H-glucose, 3H-glycine and 3H-lysine occur with similar frequency, whereas the difference in values of the absorbed dose...

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Bibliographic Details
Published in:	Genetika Vol. 25; no. 2; p. 277
Main Authors:	Pomerantseva, M D, Balonov, M I, Ramaĭa, L K, Chetchueva, M E, Zhesko, T V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-02-1989
Subjects:	Animals Deoxycytidine Glucose Glycine Lysine Male Mice Mutagens Sperm Head - radiation effects Testis - cytology Testis - radiation effects Thymidine Translocation, Genetic - radiation effects Tritium - toxicity
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Summary:	Comparative study of the genetic effect of some tritiated biogenic++ compounds and tritiated water was carried out. Reciprocal translocations induced in mice stem spermatogonia by 3H-glucose, 3H-glycine and 3H-lysine occur with similar frequency, whereas the difference in values of the absorbed doses of beta-irradiation in some cases was about two-fold. The highest genetic effect per unit of activity of 3H-nucleosides (3H-TdR and 3H-CdR) was revealed at lowest activities. The frequency of reciprocal translocations induced by 3H-TdR was twice as that induced by 3H-CdR.
ISSN:	0016-6758