Adverse effects of ketoprofen after intrauterine exposure. Value of plasma determination

• Published in: Archives de pédiatrie : organe officiel de la Société française de pédiatrie Vol. 3; no. 3; p. 248
• Main Authors: Llanas, B, Cavert, M H, Apere, H, Demarquez, J L
• Format: Journal Article
• Language: French
• Published: France 01-03-1996
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Drug Tolerance; Female; Humans; Infant, Newborn; Ketoprofen - adverse effects; Ketoprofen - blood; Ketoprofen - therapeutic use; Male; Maternal-Fetal Exchange; Obstetric Labor, Premature - prevention & control; Pregnancy; Prenatal Exposure Delayed Effects; Tocolytic Agents - adverse effects; Tocolytic Agents - therapeutic use
• ISSN: 0929-693X

Prostaglandin synthetase inhibitors have been used to prevent the onset of premature labor. But a small number of newborn infants have been reported with premature closure of the ductus arteriosus, pulmonary hypertension and/or oliguria.
Eleven neonates from seven pregnancies were admitted because they suffered from adverse effects of ketoprofen given to their mothers before delivery. The plasma ketoprofen level was measured in 6 of the neonates.
Ten of the 11 neonates had renal dysfunction which was lethal in three; two of the 11 developed cardiopulmonary complications, lethal in one. The ketoprofen concentration in plasma was high in the first few hours of life in three patients.
In the absence of precise risk factors for prognosis, repeated drug measurements in the maternal plasma before delivery and in their babies after birth could be a predictive factor.