Tissue autofluorescence damping mechanisms, sensitized by tumorotrophic dyes

Using an automated laser-fiber spectrofluorimeter, the fluorescence spectra of normal and malignant tissues sensibilized by chlorin e6 and flurenate in vivo and ex vivo were studied. A quenching of intrinsic fluorescence of sensibilized tissues was found, which was more evident in the affected regio...

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Bibliographic Details
Published in:	Biofizika Vol. 40; no. 6; p. 1308
Main Authors:	Oganesian, V A, Lalaian, A A, Aĭdinian, L E
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1995
Subjects:	Animals Humans Mice Photosensitizing Agents - pharmacology Porphyrins - pharmacology Rats Sarcoma, Experimental - chemistry Spectrometry, Fluorescence
Online Access:	Get more information
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Summary:	Using an automated laser-fiber spectrofluorimeter, the fluorescence spectra of normal and malignant tissues sensibilized by chlorin e6 and flurenate in vivo and ex vivo were studied. A quenching of intrinsic fluorescence of sensibilized tissues was found, which was more evident in the affected regions. The observed effect is related to electron excitation energy transfer from endogenous fluorophores to the photosensitizers administered. The possibility of enhancing the sensitivity of fluorescence diagnosis of malignant tumors is discussed.
ISSN:	0006-3029