Unscheduled DNA synthesis in human hair follicles after in vitro exposure to 11 chemicals: comparison with unscheduled DNA synthesis in rat hepatocytes

A new method is described to investigate unscheduled DNA synthesis (UDS) in human tissue after exposure in vitro: the human hair follicle. A histological technique was applied to assess cytotoxicity and UDS in the same hair follicle cells. UDS induction was examined for 11 chemicals and the results...

Full description

Saved in:

Bibliographic Details
Published in:	Mutation research Vol. 271; no. 3; p. 201
Main Authors:	van Erp, Y H, Koopmans, M J, Heirbaut, P R, van der Hoeven, J C, Weterings, P J
Format:	Journal Article
Language:	English
Published:	Netherlands 01-06-1992
Subjects:	Animals Autoradiography Biotransformation Cells, Cultured DNA - biosynthesis Hair - drug effects Hair - metabolism Humans Liver - cytology Liver - drug effects Liver - metabolism Mutagenicity Tests Mutagens - pharmacokinetics Mutagens - toxicity Rats Thymidine - metabolism
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!