The anti-arrhythmia effect of Rhodiola rosea and its possible mechanism

A course injection of Rhodiola rosea extract for eight days was reported to increase the resistance of experimental animals to adrenalin- or CaCl2-induced arrhythmias. Preliminary injection of naloxone in a dose of 0.5 mg/kg eliminated the antiarrhythmic effect of Rhodiola. Indomethacin had no effec...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 116; no. 8; p. 175
Main Authors:	Lishmanov, Iu B, Maslova, L V, Maslov, L N, Dan'shina, E N
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-08-1993
Subjects:	Animals Anti-Arrhythmia Agents - pharmacology Anti-Arrhythmia Agents - therapeutic use Calcium Chloride Cardiac Complexes, Premature - chemically induced Cardiac Complexes, Premature - drug therapy Disease Models, Animal Drug Evaluation, Preclinical Epinephrine Indomethacin - pharmacology Male Naloxone - pharmacology Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar Ventricular Fibrillation - chemically induced Ventricular Fibrillation - drug therapy
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Summary:	A course injection of Rhodiola rosea extract for eight days was reported to increase the resistance of experimental animals to adrenalin- or CaCl2-induced arrhythmias. Preliminary injection of naloxone in a dose of 0.5 mg/kg eliminated the antiarrhythmic effect of Rhodiola. Indomethacin had no effect the antiarrhythmic action of Rhodiola. The antiarrhythmic effect of Rhodiola course injections was assumed to be associated with the induction of opioid peptides biosynthesis.
ISSN:	0365-9615