Fatty acid composition and energy state of liver mitochondria after the administration of antioxidants of the ionol group to albino rats

• Published in: Biokhimiia (Moscow, Russia) Vol. 50; no. 10; p. 1582
• Main Authors: Zhigacheva, I V, Kaplan, E Ia
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-10-1985
• Subjects: Animals; Antioxidants - pharmacology; Butylated Hydroxytoluene - pharmacology; Energy Metabolism; Fatty Acids - metabolism; Female; Membrane Lipids - metabolism; Mitochondria, Liver - metabolism; NAD - metabolism; Oxidation-Reduction; Oxygen Consumption - drug effects; Rats; Rats, Inbred Strains
• ISSN: 0320-9725

Injections of albino rats with antioxidants of the ionol group cause cyclic changes in the energy state of liver mitochondria which are correlated with changes in the fatty acid composition of mitochondrial membranes. The increase in the degree of coupling between oxidation and phosphorylation coincides in time with the increment in the content of saturated fatty acids and a decrease in the unsaturated fatty acid content in the total fraction of mitochondrial membrane lipids. Conversely, the activation of the external pathway of NADH oxidation and a decrease of the respiratory control are correlated with the diminution of the saturated fatty acid content and an increased percentage of unsaturated fatty acids. These changes are especially well pronounced in the case of fatty acids carrying 18 carbon atoms.