Effect of actoprotectors on Ca, Mg-dependent ATPase activity in the sarcoplasmatic reticulum of rabbit muscles

The effect of different chemical compounds on Ca, Mg-dependent ATPase (Ca-ATPase) sarcoplasmic reticulum (SR) hydrolytic activity as well as their actoprotecting (AP) activity, the ability to increase organism's resistance under muscle stress and antihypoxanthic (AH) activity to increase the or...

Full description

Saved in:

Bibliographic Details
Published in:	Nauchnye doklady vysshei shkoly. Biologicheskie nauki no. 7; p. 33
Main Authors:	Kaplan, E Ia, Limantsev, A V, Moshkovskiĭ, Iu Sh, Palkin, L L, Tat'ianenko, L V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1987
Subjects:	Adaptation, Physiological - drug effects Animals Ca(2+) Mg(2+)-ATPase - antagonists & inhibitors Calcium-Transporting ATPases - antagonists & inhibitors Electron Spin Resonance Spectroscopy Hypoxia - prevention & control In Vitro Techniques Rabbits Rats Sarcoplasmic Reticulum - enzymology Structure-Activity Relationship
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The effect of different chemical compounds on Ca, Mg-dependent ATPase (Ca-ATPase) sarcoplasmic reticulum (SR) hydrolytic activity as well as their actoprotecting (AP) activity, the ability to increase organism's resistance under muscle stress and antihypoxanthic (AH) activity to increase the organism's survival under conditions of low pressure has been studied. The compounds with AP-activity have been shown to be strong inhibitors of Ca-ATPase SR hydrolytic activity. No correlation between AP-activity of the compounds and their effect on Ca-ATPase SR has been found. The membranotropic activity of actoprotectors has been shown by electronic paramagnetic resonance method. A suggestion has been made to use Ca-ATPase SR as a tested object during the forecasting actoprotecting activity of new chemical compounds.
ISSN:	0470-4606