Effect of the microiontophoretic injection of AMP and cAMP on the calcium current in the dialyzed neuron of the edible snail

The effect of microiontophoretic injection of AMP and cAMP on the calcium current was investigated in dialyzed snail neurons. It was found that microiontophoretic injection of AMP restores calcium current after its "washout" during the dialysis and enhances its stability. In this case the...

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Bibliographic Details
Published in:	Neirofiziologiia = Neurophysiology Vol. 20; no. 6; p. 769
Main Authors:	Kononenko, N I, Shcherbatko, A D
Format:	Journal Article
Language:	Russian
Published:	Ukraine 1988
Subjects:	Adenosine Monophosphate - pharmacology Animals Calcium Channels - drug effects Calcium Channels - physiology Cyclic AMP - pharmacology Dialysis Helix (Snails) - drug effects Iontophoresis Membrane Potentials - drug effects Microelectrodes Microinjections Neurons - drug effects Neurons - physiology
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Summary:	The effect of microiontophoretic injection of AMP and cAMP on the calcium current was investigated in dialyzed snail neurons. It was found that microiontophoretic injection of AMP restores calcium current after its "washout" during the dialysis and enhances its stability. In this case the current-voltage characteristic was shifted by 10 mV in the depolarizing direction. Under these conditions the iontophoretic cAMP injection into a dialyzed neuron produced a reversible decrease of the calcium current.
ISSN:	0028-2561