Significance of polyamines for the early diagnosis of spontaneous hemoblastoses in AKR mice

Polyamines levels were studied in various tissue specimens obtained from high-leukemia AKR mice aged 12 months and less. Organ tissues of leukemic animals revealed increased levels of polyamines and changes in their profile. In symptomatic mice, this was matched by relevant morphologic changes. It i...

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Bibliographic Details
Published in:	Voprosy onkologij Vol. 34; no. 2; p. 200
Main Authors:	Voronchikhina, L D, Vorozhtsova, S I, Minakov, V N, Zinov'ev, Iu V, Shkanakina, T P
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1988
Subjects:	Animals Biomarkers, Tumor Brain Chemistry Female Kidney - metabolism Liver - metabolism Lung - metabolism Lymphoma - metabolism Male Mice Mice, Inbred AKR Polyamines - biosynthesis Putrescine - biosynthesis Spermidine - biosynthesis Spermine - biosynthesis Spleen - metabolism Thymus Gland - metabolism
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Summary:	Polyamines levels were studied in various tissue specimens obtained from high-leukemia AKR mice aged 12 months and less. Organ tissues of leukemic animals revealed increased levels of polyamines and changes in their profile. In symptomatic mice, this was matched by relevant morphologic changes. It is inferred that putrescine is a marker of latent leukemia development.
ISSN:	0507-3758