Clinical effect of nitrates (Olicard 40) and their influence on deforming of erythrocytes against the background of 24-hour catecholaminuria

• Published in: Wiadomości lekarskie (1960) Vol. 47; no. 17-18; p. 641
• Main Authors: Dłuźniewski, M, Lada, W, Raczkowska, A, Mamcarz, A, Podogrodzka, B, Swiatowiec, A, Jurgiel, R, Sitkiewicz, W, Pawińska, M
• Format: Journal Article
• Language: Polish
• Published: Poland 01-09-1994
• Subjects: Adult; Aged; Catecholamines - urine; Erythrocyte Deformability - drug effects; Exercise Test; Female; Follow-Up Studies; Humans; Isosorbide Dinitrate - analogs & derivatives; Isosorbide Dinitrate - pharmacology; Isosorbide Dinitrate - therapeutic use; Male; Middle Aged; Myocardial Ischemia - drug therapy; Myocardial Ischemia - physiopathology; Nitric Oxide - physiology; Vasodilator Agents - pharmacology; Vasodilator Agents - therapeutic use
• ISSN: 0043-5147

Progress in the investigations upon factors influencing the course of the ischemic heart disease focused our attention on the deformability of erythrocytes. That attribute of the red blood cells (RBC) is described by their susceptibility to changes in shape without changing volume. Because of that feature, RBC can reach the smallest capillaries of the circulatory system. The aim of the study was to determine the influence of mononitrates (Olicard Ret.) on the deformability of RBC (EDI) in correlation to the clinical course of the ischemic heart disease and to evaluate the role of catecholamines in the course of the disease and their influence upon EDI. 30 patients (pts) treated with mononitrates for 4 weeks were enrolled into the study. In 27 pts clinical improvement was recorded, as evaluated by the results of repeated exercise tests and changes in the number of anginal attacks. Mean weekly number of anginal attacks decreased from 6.2 to 2.1 (p < 0.05), and parameters of exercise tests improved: DP/Wmac decreased from 0.694 to 0.479 (p < 0.001) and maximal workload attained increased from 6.8 to 9.0 METS (p < 0.001). Correspondingly to the clinical improvement, beneficial changes in RBC deformability were seen: 0.033 vs 0.040 (p < 0.01). Correlation factor for changes in EDI (r = 0.628) was higher than that for the number of anginal attacks (r = 0.589), but lower than the correlation factor for exercise test parameters (r = 0.969 for DP/Wmax and r = 0.858 for METS). There were no significant changes in the urinary output of catecholamines and no correlations were seen between urinary output of adrenaline, noradrenaline and EDI.