Preneoplastic lesions associated with carcinoma of the stomach: retrospective study of 125 gastrectomy pieces

A study was made of 125 gastrectomy pieces with gastric carcinoma in which metaplastic and dysplastic changes on the intact gastric mucosa adjacent to the tumor were analyzed. Both incomplete intestinal metaplasia and different types of dysplasia were more frequently and significantly associated wit...

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Bibliographic Details
Published in:	Revista espanola de las enfermedades del aparato digestivo Vol. 75; no. 6 Pt 2; p. 676
Main Authors:	Anquela, J M, Rodríguez Muñoz, S, Ruiz Liso, J M, Gimeno Esteras, E, Sanz Millán, M, Almendral López, M L
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-06-1989
Subjects:	Aged Female Gastric Mucosa - pathology Humans Intestines - pathology Male Metaplasia Middle Aged Precancerous Conditions - pathology Retrospective Studies Stomach Neoplasms - pathology
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Summary:	A study was made of 125 gastrectomy pieces with gastric carcinoma in which metaplastic and dysplastic changes on the intact gastric mucosa adjacent to the tumor were analyzed. Both incomplete intestinal metaplasia and different types of dysplasia were more frequently and significantly associated with carcinomas of intestinal pattern than with diffuse ones (p less than 0.001). Jass type I dysplasia was more frequent in well-differentiated carcinomas, while Jass type II was more common in relatively undifferentiated tumors, the difference being highly significant (p less than 0.001). Our results and those of other studies in the literature suggest a pathogenic relationship only between preneoplastic lesions and gastric carcinoma of intestinal pattern, which probably includes entities that can be differentiated by pathogenesis to judge from the variations in the dysplastic changes observed.
ISSN:	0034-9437