The immunobiological properties of the antigenic preparations obtained from a vaccinal strain of Klebsiella pneumoniae 204 grown in media of differing compositions

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 7; p. 43
• Main Authors: Miriasova, L V, Basnak'ian, I A, Egorova, N B, Kurbatova, E A, Reshilov, L N, Krylova, A Iu, Efimtseva, O V, Shagam, N L, Salov, V F
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-07-1990
• Subjects: Animals; Antigens, Bacterial - immunology; Antigens, Bacterial - isolation & purification; Antigens, Bacterial - toxicity; Bacterial Vaccines - immunology; Bacterial Vaccines - isolation & purification; Bacterial Vaccines - toxicity; Culture Media; Immunization; Klebsiella pneumoniae - growth & development; Klebsiella pneumoniae - immunology; Klebsiella pneumoniae - ultrastructure; Lethal Dose 50; Mice; Microscopy, Electron
• ISSN: 0372-9311

In the technology of the cultivation of K. pneumoniae vaccine strain 204 with a view to obtaining biomass for the production of antigenic preparations the traditionally used culture medium with full nutritional value has been replaced by the alternative variant of synthetic medium. The specific physiological and morphological features of this strain grown in synthetic culture medium have been studied and described. Irrespective of the composition of the culture media used for cultivation, the antigenic preparations have been shown to have no difference in their chemical composition, immunogenic and toxic properties.