The properties of the glucocorticoid-sensitive alkaline proteinases of target organs in rats

The preliminary characterization of glucocorticoid-sensitive alkaline proteinases of rat thymus and liver was carried out. The role of active serine and cysteine residues in proteolysis was estimated. The influence of Ca++, Mg++, Fe++, Fe , Cu++, EDTA and EGTA on enzymes activity was studied. It is...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 114; no. 12; p. 615
Main Authors:	Ogurtsov, S I, Dukhanin, A S, Mitroshina, S Iu
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-12-1992
Subjects:	Animals Dexamethasone - pharmacology Dose-Response Relationship, Drug Endopeptidases - drug effects Endopeptidases - metabolism Enzyme Activation - drug effects Indicators and Reagents Liver - drug effects Liver - enzymology Male Rats Sodium Radioisotopes Temperature Thymus Gland - drug effects Thymus Gland - enzymology
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Summary:	The preliminary characterization of glucocorticoid-sensitive alkaline proteinases of rat thymus and liver was carried out. The role of active serine and cysteine residues in proteolysis was estimated. The influence of Ca++, Mg++, Fe++, Fe , Cu++, EDTA and EGTA on enzymes activity was studied. It is shown that alkaline proteinases of thymus and liver have similar properties, but are not completely identical.
ISSN:	0365-9615