Use of computers for detecting the dynamics of changes in the cardiac adaptation reserves of alcoholism patients treated with nonachlazine

• Published in: Biulleten' eksperimental'noi biologii i meditsiny Vol. 93; no. 5; p. 68
• Main Authors: Kaverina, N V, Berdiaev, S Iu, Mel'nikova, T S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-05-1982
• Subjects: Adaptation, Physiological - drug effects; Adolescent; Adult; Alcoholism - complications; Alcoholism - drug therapy; Cardiomyopathy, Alcoholic - diagnosis; Diagnosis, Computer-Assisted; Electrocardiography; Heart - drug effects; Heart Rate - drug effects; Humans; Male; Middle Aged; Nonachlazine - therapeutic use; Phenothiazines - therapeutic use
• ISSN: 0365-9615

To reveal latent cardiac pathology in alcoholic patients'--the adaptation mechanisms adjusting the heart to the exercise test were quantitatively evaluated. The computer-made histograms of the cardiac rhythm of 30 practically healthy humans and 24 alcoholic patients showed before, during and after the exercise test that the variation range of the R-R interval was drastically decreased in alcoholic patients as compared to normal, while their mode was shifted towards shorter cardiointervals and had an increased amplitude. When the alcoholic patients were exposed to the exercise tests the shifts of the cardiointerval parameters in them were sharply different from those observed in the healthy subjects and after the test was over, the initial cardiac rhythm parameters failed to reappear within more than 3 min. Nonachlazin treatment of alcoholic cardiomyopathy increased the exercise tolerance estimated on the basis of the computer-processed cardiac rhythm, contributing to the reappearance of the normal clinical picture in the patients.