Changes in carbohydrate metabolism before and after the development of focal cerebral ischemia. III. Function of the diencephalon

• Published in: Ceskoslovenska neurologie a neurochirurgie Vol. 52; no. 3; p. 193
• Main Authors: Bartko, D, Zúzi, M, Danisová, J, Brezná, M
• Format: Journal Article
• Language: Slovak
• Published: Czech Republic 01-05-1989
• Subjects: Adult; Blood Glucose - metabolism; Diencephalon - physiopathology; Hemodynamics - drug effects; Humans; Ischemic Attack, Transient - blood; Ischemic Attack, Transient - physiopathology; Lipopolysaccharides - pharmacology; Middle Aged
• ISSN: 0301-0597

The purpose of the investigation was to assess whether the mechanism of reduced glucose tolerance in focal ischaemia of the brain can be considered a functional disorder of the regulatory brain centres or a manifestation of inadequate glucose utilization due to impaired insulin secretion. The function of centres regulating metabolic processes was tested by the i.v. administration of Pyrifer. It was revealed that after Pyrifer administration a parallel rise of the investigated values does not occur (i.e. number of leucocytes, body temperature, pulse, systolic and diastolic pressure, blood sugar level), the maximum values do not reach the levels of the control group, their rise is retarded, persists twice as long as in the control group and does not return to baseline values in the appropriate time. A pathological constellation of responses was recorded in 85.71% of the cases. A similar trend of changes was found also in a group of arteriosclerotic and hypertonic patients although in a lower percentage. The results confirmed the assumption that in the mechanism of reduced glucose tolerance in the periphery an important part is played by the impaired function of regulating centres in the diencephalon.