Effect of inhibitors of RNA and protein synthesis on audiogenic epileptiform reactions in rats of the KM line

Injection of actinomycin D, puromycin and cycloheximide change the genetically determined reaction of rats to acoustic stimuli up to the appearance of resistance to sound. The change in the nature of audiogenic epileptiform seizures correlates with the disturbance of the RNA and protein synthesis in...

Full description

Saved in:

Bibliographic Details
Published in:	Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 26; no. 5; p. 1066
Main Authors:	Karasik, G I, Korochkin, L I, Maksimovskiĭ, L F
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1976
Subjects:	Acoustic Stimulation Animals Anticonvulsants Brain - metabolism Cycloheximide - therapeutic use Dactinomycin - therapeutic use Nerve Tissue Proteins - biosynthesis Puromycin - therapeutic use Rats RNA - biosynthesis Seizures - etiology Seizures - metabolism Seizures - prevention & control Time Factors
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Injection of actinomycin D, puromycin and cycloheximide change the genetically determined reaction of rats to acoustic stimuli up to the appearance of resistance to sound. The change in the nature of audiogenic epileptiform seizures correlates with the disturbance of the RNA and protein synthesis in the experimental animals brain. The appearance of sound resistance does not correlate with the degree of inhibition of protein synthesis in the brain. It is assumed that the antiseizure effect of the drugs used is possibly due to their action on the neuromediator systems of the brain.
ISSN:	0044-4677