Adaptive changes in brain metabolism during chronic alcoholic intoxication

• Published in: Voprosy biokhimii mozga Vol. 13; p. 303
• Main Authors: Sytinskiĭ, I A, Bezborodov, A M, Blagova, O E, Konovalova, N N, Kopelevich, V M
• Format: Journal Article
• Language: Russian
• Published: Armenia (Republic) 1978
• Subjects: 4-Aminobutyrate Transaminase - metabolism; Alanine Transaminase - metabolism; Alcoholism - enzymology; Alcoholism - physiopathology; Animals; Aspartate Aminotransferases - metabolism; Brain - enzymology; Cerebellum - enzymology; Glutamate Decarboxylase - metabolism; Humans; Malate Dehydrogenase - metabolism; Male; Motor Activity; Rats; Substance Withdrawal Syndrome - enzymology; Substance Withdrawal Syndrome - physiopathology; Succinate Dehydrogenase - metabolism
• ISSN: 0507-2972

Chronically alcoholized intoxication (1.5--2 months) induces adaptation of cerebral neurones to changing equilibrium states of biochemical processes by altering the activity of enzymes of GABA metabolism, reduction of alanine and aspartate transaminase activity and increase of LDH and succinate dehydrogenase activity. In the cerebellum and cerebral hemispheres during alcohol abstinacy the activity of GABA-T, succinate dehydrogenase and aspartate transaminase was reduced while that of LDH and alanine transaminase was increased. The administration of fusarinic acid (100 mg/kg i. p.) to control animals induced a sharp increase of GAD activity in both structures of the brain. The stimulatory effects of fusarinic acid were not observed when it was administered to animals receiving alcohol chronically. Motor activity or rats was markedly reduced during chronical alcoholism and the first days of alcohol abstinacy (24--48 h), as well as following injection fusarinic acid and homopantothenic acid. The increase of locomotion and the vertical component of motor activity was observed only following one week or one month after alcohol abstinacy.