Obtaining 14-oxycarminomycin and a study of its antitumor activity
The authors obtained 14-oxykarminomycin by alkaline hydrolysis of 14-bromokarminomycin. On two-fold intravenous administration to mice with lymphosarcoma, strain L10-1, 14-oxycarminomycin showed the same toxicity as karminomycin. The preparation had the same selective antitumor activity as karminomy...
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| Published in: | Antibiotiki Vol. 22; no. 8; p. 693 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | Russian |
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Russia (Federation)
01-08-1977
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| Abstract | The authors obtained 14-oxykarminomycin by alkaline hydrolysis of 14-bromokarminomycin. On two-fold intravenous administration to mice with lymphosarcoma, strain L10-1, 14-oxycarminomycin showed the same toxicity as karminomycin. The preparation had the same selective antitumor activity as karminomycin. |
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| AbstractList | The authors obtained 14-oxykarminomycin by alkaline hydrolysis of 14-bromokarminomycin. On two-fold intravenous administration to mice with lymphosarcoma, strain L10-1, 14-oxycarminomycin showed the same toxicity as karminomycin. The preparation had the same selective antitumor activity as karminomycin. |
| Author | Vasekina, V F Bazhanov, V S Povarov, L S |
| Author_xml | – sequence: 1 givenname: L S surname: Povarov fullname: Povarov, L S – sequence: 2 givenname: V S surname: Bazhanov fullname: Bazhanov, V S – sequence: 3 givenname: V F surname: Vasekina fullname: Vasekina, V F |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/578668$$D View this record in MEDLINE/PubMed |
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| Snippet | The authors obtained 14-oxykarminomycin by alkaline hydrolysis of 14-bromokarminomycin. On two-fold intravenous administration to mice with lymphosarcoma,... |
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| SubjectTerms | Animals Antibiotics, Antineoplastic - chemical synthesis Carubicin - analogs & derivatives Carubicin - chemical synthesis Carubicin - therapeutic use Carubicin - toxicity Drug Evaluation Hydrolysis Lethal Dose 50 Lymphoma, Non-Hodgkin - drug therapy Mice Neoplasms, Experimental - drug therapy |
| Title | Obtaining 14-oxycarminomycin and a study of its antitumor activity |
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