Obtaining 14-oxycarminomycin and a study of its antitumor activity

The authors obtained 14-oxykarminomycin by alkaline hydrolysis of 14-bromokarminomycin. On two-fold intravenous administration to mice with lymphosarcoma, strain L10-1, 14-oxycarminomycin showed the same toxicity as karminomycin. The preparation had the same selective antitumor activity as karminomy...

Full description

Saved in:

Bibliographic Details
Published in:	Antibiotiki Vol. 22; no. 8; p. 693
Main Authors:	Povarov, L S, Bazhanov, V S, Vasekina, V F
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-08-1977
Subjects:	Animals Antibiotics, Antineoplastic - chemical synthesis Carubicin - analogs & derivatives Carubicin - chemical synthesis Carubicin - therapeutic use Carubicin - toxicity Drug Evaluation Hydrolysis Lethal Dose 50 Lymphoma, Non-Hodgkin - drug therapy Mice Neoplasms, Experimental - drug therapy
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The authors obtained 14-oxykarminomycin by alkaline hydrolysis of 14-bromokarminomycin. On two-fold intravenous administration to mice with lymphosarcoma, strain L10-1, 14-oxycarminomycin showed the same toxicity as karminomycin. The preparation had the same selective antitumor activity as karminomycin.
ISSN:	0003-5637