Differences in the efficacy of gutimine alpha-ketoglutarate in the hypoxic and motor forms of hypoxia

• Published in: Farmakologiia i toksikologiia Vol. 41; no. 1; p. 97
• Main Authors: Bykov, N P, Ronin, M Ia, Strelkov, R B
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-01-1978
• Subjects: Altitude; Amidines - therapeutic use; Animals; Atmosphere Exposure Chambers; Drug Evaluation, Preclinical; Hypoxia - drug therapy; Hypoxia - mortality; Ketoglutaric Acids - therapeutic use; Male; Mice; Physical Exertion - drug effects; Thiourea - analogs & derivatives; Thiourea - therapeutic use; Time Factors
• ISSN: 0014-8318

When used in a dose of 100 mg/kg gutimine alpha-ketogluterate exerts a pronounced antihypoxic action in hypo- and normabaric hpoxic hypoxia ("lifting" albino mice in a pressure chamber to an "altitude" of 10000 m, rarefaction down to 198.7 mm of Hg, PO2--42 mm Hg, the chamber atmosphere containing 5.4 vol % of oxygen with the animals placed in the hermetically sealed chamber containing 5% of oxygen and 95% of nitrogen at 760 mm Hg). The absence of antihypoxic effect of the drug and exygen with the motor form of hypoxia (swimming test with the weight mass of 10 per cent of the body mass) bears evidence to the fact that the pathogenetic mechanisms in these two forms of hypoxia are dissimilar. An inference is drawn to the effect that the protective action of the drug may be associated with correction of the oxygen cycle in the organism.