Synthesis of beta, beta'-subunits of RNA-polymerase in E. coli cells starved for an essential amino acid

The differential rate of RNA-polymerase beta,beta'-subunits synthesis in E. coli rel+ and rel- cells starved for an essential amino acid, i. e. leucine, is decreased. Inhibition of the rpo BC genes expression proceeds faster in the rel A strain. Guanosine tetraphosphate within the concentration...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 44; no. 10; p. 1859
Main Authors:	Lideman, L F, Ponomarenko, O I, Shakulov, R S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-10-1979
Subjects:	DNA-Directed RNA Polymerases - biosynthesis Escherichia coli - drug effects Escherichia coli - enzymology Guanosine Tetraphosphate - pharmacology Kinetics Leucine - metabolism Macromolecular Substances Mutation Species Specificity Transcription, Genetic
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Summary:	The differential rate of RNA-polymerase beta,beta'-subunits synthesis in E. coli rel+ and rel- cells starved for an essential amino acid, i. e. leucine, is decreased. Inhibition of the rpo BC genes expression proceeds faster in the rel A strain. Guanosine tetraphosphate within the concentration range of 0,2--0,6 mM specifically inhibits lambda drifd18 DNA directed beta,beta'-subunits synthesis in vitro. rpo BC genes are believed to be subject to a weak "stringent control".
ISSN:	0320-9725