Flocculant interaction with native antibiotic solutions. An examination of the mechanism of the process

• Published in: Antibiotiki Vol. 23; no. 2; p. 138
• Main Authors: Vernikova, L M, Zhukovskaia, S A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-02-1978
• Subjects: Anti-Bacterial Agents - pharmacology; Drug Interactions; Flocculation; Flocculation Tests - instrumentation; Particle Size; Penicillins - pharmacology; Solutions
• ISSN: 0003-5637

Some characteristics of the fermentation broth filtrates, i.e. concentration of the disperse particles and some of their parameters (projected length, area, distribution of the particles along the maximum chord) were determined and estimated after flocculation. It was shown that the floccules were mainly formed as fine colloid admixtures present not only in "turbid", but also in visually transparant solutions. It was found that the mechanism of flocculation was rather complicated and not always similar for different batches of the fermentation broth filtrate: it was, in particular, affected by the electrostatic interactions, the flocculant interaction with inorganic reagents, bridge-forming processes.