Interaction of mitogenic lectins with lymphocyte plasma membranes

It is shown that mitogenic stimuli from concanavalin A and phytohemagglutinin are summed up in the time. Under given experimental conditions each of the mitogens used did not induce mitogenesis when the interaction with lymphocytes continued for 14 and/or 20 hours. The results obtained are discussed...

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Bibliographic Details
Published in:	Biulleten' eksperimental'noi biologii i meditsiny Vol. 88; no. 7; p. 89
Main Authors:	Sitkovskiĭ, M V, Shestakova, S V, Kozlov, Iu P
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1979
Subjects:	Animals Cell Membrane - drug effects Concanavalin A - pharmacology DNA - metabolism In Vitro Techniques Lectins - pharmacology Lymphocytes - drug effects Lymphocytes - metabolism Mitogens Phytohemagglutinins - pharmacology Rats Thymidine - metabolism Time Factors
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Summary:	It is shown that mitogenic stimuli from concanavalin A and phytohemagglutinin are summed up in the time. Under given experimental conditions each of the mitogens used did not induce mitogenesis when the interaction with lymphocytes continued for 14 and/or 20 hours. The results obtained are discussed from the point of view of the cell-to-cell interaction between the lymphocytes. It is assumed that the ability of the stimuli to sum up in the time underlies the nonspecific mechanism of defense from tolerance.
ISSN:	0365-9615