Mutagenic activity of benzonal

Benzonalum mutagenic activity was demonstrated in a dominant lethal test on mice. The late spermatids stage proved to be the most sensitive in this respect. The benzonalum did not evoke any cytogenetic activity, that was shown by counting chromosome aberrations in metaphases of the bone marrow cells...

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Bibliographic Details
Published in:	TSitologiia i genetika Vol. 10; no. 2; p. 99
Main Authors:	Fonshteĭn, L M, Zolotareva, G N, Iskhakova, E N, Shapiro, A A
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-03-1976
Subjects:	Animals Barbiturates - toxicity Bone Marrow - drug effects Bone Marrow Cells Chromosome Aberrations Genes, Dominant Genes, Lethal Male Mice Mutagens Mutation Salmonella typhimurium - drug effects Spermatozoa - drug effects
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Summary:	Benzonalum mutagenic activity was demonstrated in a dominant lethal test on mice. The late spermatids stage proved to be the most sensitive in this respect. The benzonalum did not evoke any cytogenetic activity, that was shown by counting chromosome aberrations in metaphases of the bone marrow cells in vivo and did not induce gene mutations in tester trains of Salmonella typhimurium in vitro and in vivo (a host-mediated assay).
ISSN:	0564-3783