Participation of glutamate and alanine in amino acid biosynthesis, in lipogenesis, and in gluconeogenesis in the brain

The participation of glutamate and alanine in lipogenesis and gluconeogenesis of brain was investigated. 5(14)C glutamate was injected intracisternally in an amount of 5 mcCu/l g tissue and 3(14)C-alanine was injected subcutaneously 30 mcCu/100 g body weight. Labels from glutamate and alanine were r...

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Bibliographic Details
Published in:	Voprosy biokhimii mozga Vol. 13; p. 248
Main Authors:	Prokhorova, M I, Osadchaia, L M, Vilkova, V A, Eshchenko, N D, Zakharova, L I
Format:	Journal Article
Language:	Russian
Published:	Armenia (Republic) 1978
Subjects:	Alanine - metabolism Amino Acids - biosynthesis Animals Brain - metabolism Citrates - biosynthesis Fatty Acids - biosynthesis Gluconeogenesis Glutamates - metabolism Ketoglutaric Acids - metabolism Lipids - biosynthesis Rats
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Summary:	The participation of glutamate and alanine in lipogenesis and gluconeogenesis of brain was investigated. 5(14)C glutamate was injected intracisternally in an amount of 5 mcCu/l g tissue and 3(14)C-alanine was injected subcutaneously 30 mcCu/100 g body weight. Labels from glutamate and alanine were recovered in different lipid franctions -- in phospholipids, glycerides, free fatty acids and cholesterol, as well as in glucose and glycogen. An intensive incorporation of label from 5(14)C glutamate into various amino acids--aspartic acid, glutamine, serine, glycine and alanine--was demonstrated. The data presented indicate the participation of amino acids in lipogenesis and gluconeogenesis of brain.
ISSN:	0507-2972