Organ specific water-soluble cerebral cortex proteins; possible participation in physiological functions and pathologic manifestations

• Published in: Voprosy biokhimii mozga Vol. 13; p. 144
• Main Authors: Vartanian, M E, Burbaeva, G Sh, Ignatov, S A, Nazarian, K B
• Format: Journal Article
• Language: Russian
• Published: Armenia (Republic) 1978
• Subjects: Amyotrophic Lateral Sclerosis - immunology; Antigens - isolation & purification; Autoantibodies; Cerebral Cortex - immunology; Glycoproteins - immunology; Humans; Multiple Sclerosis - immunology; Nerve Tissue Proteins - immunology; Organ Specificity; Schizophrenia - immunology
• ISSN: 0507-2972

The spectre of active antigens in brain is studied. The presence of 3 protein and 3 glycoprotein brain specific antigens is demonstrated. The possible participation of brain specific antigens in increased antibody formation in schizophrenics, multiple sclerosis and lateral ammiotrophic sclerosis is studied. The data obtained indicate the role of brain specific antigens to autoimmunity in those patients. The possible participation of one of the specific antigens of the brain, sialoglycoprotein GP-350, in physiological processes connected with the mechanism of memory is also studied. In experiments of inbred trained rats an activation of the synthesis of GP-350 is observed.