MicroRNA‐155 regulates interferon‐γ production in natural killer cells via Tim‐3 signalling in chronic hepatitis C virus infection

Summary Host immune responses must be tightly regulated by an intricate balance between positive and negative signals while fighting pathogens; persistent pathogens may usurp these regulatory mechanisms to dampen host immunity to facilitate survival in vivo. Here we report that Tim‐3, a negative sig...

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Bibliographic Details
Published in:	Immunology Vol. 145; no. 4; pp. 485 - 497
Main Authors:	Cheng, Yong Q., Ren, Jun P., Zhao, Juan, Wang, Jia M., Zhou, Yun, Li, Guang Y., Moorman, Jonathan P., Yao, Zhi Q.
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Ltd 01-08-2015
Subjects:	Adult Aged Cell Line Female Hepatitis A Virus Cellular Receptor 2 hepatitis C virus Hepatitis C, Chronic - immunology Hepatitis C, Chronic - pathology Hepatocytes - immunology Hepatocytes - pathology Humans Interferon-gamma - immunology interferon‐γ Killer Cells, Natural - immunology Killer Cells, Natural - pathology Male Membrane Proteins - immunology MicroRNAs - immunology microRNA‐155 Middle Aged natural killer cells Original signal transducer and activator of transcription‐5 Signal Transduction - immunology T-Box Domain Proteins - immunology T‐cell immunoglobulin and mucin domain protein‐3 Up-Regulation - immunology microRNA-155 hepatitis C virus natural killer cells interferon-γ T-cell immunoglobulin and mucin domain protein-3 signal transducer and activator of transcription-5
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