Amitriptyline up‐regulates connexin43‐gap junction in rat cultured cortical astrocytes via activation of the p38 and c‐Fos/AP‐1 signalling pathway

Background and Purpose Intercellular communication via gap junctions, comprised of connexin (Cx) proteins, allow for communication between astrocytes, which in turn is crucial for maintaining CNS homeostasis. The expression of Cx43 is decreased in post‐mortem brains from patients with major depressi...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 171; no. 11; pp. 2854 - 2867
Main Authors:	Morioka, N, Suekama, K, Zhang, F F, Kajitani, N, Hisaoka‐Nakashima, K, Takebayashi, M, Nakata, Y
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-06-2014 BlackWell Publishing Ltd
Subjects:	amitriptyline Amitriptyline - pharmacology Animals Antidepressants Antidepressive Agents, Tricyclic - pharmacology AP‐1 astrocyte Astrocytes - drug effects Astrocytes - physiology Cell Communication - drug effects Cells, Cultured Communication Connexin 43 - metabolism connexin43 gap junction Gap Junctions - drug effects Gap Junctions - physiology major depressive disorder p38 p38 Mitogen-Activated Protein Kinases - metabolism Proto-Oncogene Proteins c-fos - metabolism Rats, Wistar Research Papers Transcription Factor AP-1 - metabolism Up-Regulation amitriptyline connexin43 major depressive disorder p38 antidepressants gap junction AP-1 astrocyte
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