Determinants of human cerebral pressure–flow velocity relationships: new insights from vascular modelling and Ca2+ channel blockade

Non‐technical summary Brain function is critically dependent on the regulation of cerebral blood flow (CBF) by cerebral blood vessels. We show that a mechanical blood vessel property called compliance plays an important role in determining the way cerebral blood vessels respond to changes in blood...

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Bibliographic Details
Published in:	The Journal of physiology Vol. 589; no. 13; pp. 3263 - 3274
Main Authors:	Tzeng, Yu‐Chieh, Chan, Gregory S. H., Willie, Christopher K., Ainslie, Philip N.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-07-2011 Wiley Subscription Services, Inc Blackwell Science Inc
Subjects:	Adult Blood Flow Velocity - drug effects Blood Flow Velocity - physiology Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Blood vessels Brain Calcium Calcium Channel Blockers - pharmacology Calcium Signaling - drug effects Calcium Signaling - physiology Cardiovascular Cerebral blood flow Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Cerebrovascular diseases Compliance Compliance - drug effects Compliance - physiology Dementia disorders Electrocardiography - drug effects Electrocardiography - methods Hemodynamics Humans Male Middle Cerebral Artery - drug effects Middle Cerebral Artery - physiology Models, Molecular Nimodipine Nimodipine - pharmacology Respiration - drug effects Stroke Young Adult
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