Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway

We investigated here the mechanism of cytoprotection of nitric oxide ( • NO) in bovine aortic endothelial cells treated with H 2 O 2 . NONOates were used as • NO donors that released • NO slowly at a well defined rate in the extracellular and intracellular milieus. H 2 O 2 -mediated intracellular di...

Full description

Saved in:

Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 100; no. 19; pp. 10653 - 10658
Main Authors:	Kotamraju, Srigiridhar, Tampo, Yoshiko, Keszler, Agnes, Chitambar, Christopher R, Joseph, Joy, Haas, Arthur L, Kalyanaraman, B
Format:	Journal Article
Language:	English
Published:	United States National Acad Sciences 16-09-2003 National Academy of Sciences
Subjects:	Aconitate Hydratase - metabolism Animals Apoptosis - physiology Biochemistry Biological Sciences Cattle Cells Cysteine Endopeptidases - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fluorescence Glutathione - metabolism Hydrogen Peroxide - antagonists & inhibitors Hydrogen Peroxide - metabolism Iron Regulatory Protein 1 - metabolism Multienzyme Complexes - metabolism Nitric oxide Nitric Oxide - physiology Oxidative Stress Proteasome Endopeptidase Complex Receptors, Transferrin - physiology Ubiquitin - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!