Up‐regulation of SPINT2/HAI‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion

The role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal stromal cell (BMMSC) contribution to disease progression remains poorly explored. We previously reported that the expression of serine protease in...

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Bibliographic Details
Published in:	Journal of cellular and molecular medicine Vol. 23; no. 2; pp. 1562 - 1571
Main Authors:	Roversi, Fernanda Marconi, Cury, Nathalia Moreno, Lopes, Matheus Rodrigues, Ferro, Karla Priscila, Machado‐Neto, João Agostinho, Alvarez, Marisa Claudia, Santos, Gabriela Pereira, Giardini Rosa, Renata, Longhini, Ana Leda, Duarte, Adriana da Silva Santos, Pericole, Fernando Vieira, Favaro, Patricia, Yunes, José Andres, Saad, Sara Teresinha Olalla
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01-02-2019
Subjects:	Azacitidine - pharmacology Cell Adhesion - drug effects Cell Line, Tumor Cell Survival - drug effects de novo acute myeloid leukaemia Female Humans Integrin alpha2 - genetics Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Male Membrane Glycoproteins - genetics Mesenchymal Stem Cells - drug effects mesenchymal stromal cell methylation microenvironment niche Middle Aged myelodysplastic syndromes Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - pathology Neoplastic Stem Cells - drug effects Original Tumor Microenvironment - drug effects mesenchymal stromal cell microenvironment niche methylation myelodysplastic syndromes de novo acute myeloid leukaemia
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